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September 21, 2023

If dog lovers are aware of CYP2B11 deficiency dogs, they likely think of sighthounds. The list of breeds with the CYP2B11-H3 gene mutation, though, reaches far beyond greyhounds and the like. CYP2B11 deficiency dogs pose greater risks of complications with anesthesia, including recovering more slowly. Basically, it's because the gene mutation results in less CYP2B11, and that means their bodies are much slower eliminating certain medications.

What is CYP2B11 Deficiency in Dogs?

It's caused by a mutated gene that results in lower CYP2B11, which is an enzyme needed to process and eliminate certain types of injectable anesthetic drugs that veterinarians typically use. 

What Drugs Affect CYP2B11 Deficiency Dogs More?

It's typically veterinary injectable anesthetic drugs such as:

  • Thiopental
  • Thiamylal
  • Propofol
  • Ketamine
  • Midazolam
  • Medetomidine

What's the Approximate Frequency of CYP2B11 Deficiency in At-Risk Dog Breeds?

CYP2B11 deficiency dogs - at risk breeds approximate frequency

For those using screen readers or who prefer text to charts, here are the percentages by at-risk breed:

  • 59% Greyhound (AKC)
  • 28% Rhodesian ridgebacks
  • 26% Borzoi
  • 17% Greyhound (NGA)
  • 12% Golden retriever
  • 11% Italian greyhound
  • 11% Whippet
  • 11% Scottish deerhound
  • 8% Border collie
  • 7% Silken windhound
  • 6% Spanish sighthound
  • 6% Labrador retriever
  • 5% Windsprite (longhaired whippet)
  • 3% Ibizan hound
  • 2% Crossbreed

I bolded the dog breeds definitely OUTSIDE the sighthound world for emphasis. I looked it up, and I guess Rhodesian ridgebacks are in the hound group. I did NOT know that. 

What to do about CYP2B11 Deficiency Dogs?

Especially if your dog is NOT a sighthound, let your veterinarian know if your dog carries the CYP2B11-H3 gene mutation. 

I'm honestly not sure if any of the current dog DNA tests actually look for this mutation. I once tried to get a list of the things tested by the Royal Canin Genetic Health Analysis (essentially Wisdom Panel), and they refused to tell me. 

I just searched on the Embark site, and nothing came up for CYP2B11 either. We've used Embark for Mr. Stix and a couple of foster puppies. 

CYP2B11 deficiency dogs - dna test not included graphic
About the Author Roxanne Hawn

Trained as a traditional journalist and based in the Rocky Mountains of Colorado, USA, I'm a full-time freelance writer for magazines, websites, and private clients. My areas of specialty include everything in the lifestyles arena, including health and home, personal finance and other consumer interests, relationships and trends, people and business profiles ... and, of course, all things pet related.

I don't just love dogs. I need them in my life. Seriously.

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