As I mentioned last week, the American College of Veterinary Internal Medicine held its annual forum in Denver recently, and I got the chance to attend one of the four days. Here is a brief overview of some of what I did, saw, and learned.
Because these sessions target veterinary specialists, they’re often highly technical, but having written about veterinary medicine since around 1995, I hung in there pretty well … even with the hard stuff. So, I’ll do my best to hit a few highlights today. More to come as I have time.
Breed-Associated Differential microRNA Expressions in Canine Osteosarcoma
Because the session I hoped to attend first on research into raw diets for pets got cancelled when the presenter got crazy, icky travel germs, I instead attended this bone cancer session.
Researchers in human medicine have found implications of microRNA playing a fundamental role in both cancer initiation and cancer progression. So, veterinary oncologists began looking for this gene expression in breeds of dogs known to be at higher risk of bone cancer:
- Golden retrievers
- Rottweilers
- Greyhounds (the racing kind, not the AKC kind)
They did indeed find “significant correlations” between breed and microRNA expressions. The “heat maps” show how much of this microRNA they found in the dogs tested, with Goldens having the most active heat maps.
Now, the trick is to figure out what biological consequences dogs might experience based on these levels of microRNA expression. For example, the next step might be to look at dogs in these breeds who do NOT have osteosarcoma and compare their results to those in the same breeds who do.
Phase I Evaluation of Vinblastine / Palladia Combination in Dogs With Mast Cell Tumors
Mast cell tumors are a common form of cancer in dogs (about 20% of all skin tumors in dogs). Because we know that combining various chemotherapy drugs often works well in treating various kinds of human cancers, the researchers set out to explore safe doses of these two cancer drugs together in dogs.
Basically, oncologists look to combine drugs that have:
- Documented activity (meaning they work on the cancer in question)
- Different mechanisms of activity (meaning they work on the cancer in different ways)
- Toxicity affects that do NOT overlap (to lessen possible side-effects)
- An effective way to schedule drug timing for peak tissue to recovery
Vinblastine and Palladia meet those criteria and showed “an objective clinical response” of 71% in this phase I trial. In other words, it sure looked like it worked well. Next up, phase II and phase III trials.
In the meantime, these oncologists are recommending a sequential combination (rather than concurrent combination) of these two drugs. For example, an induction dose of Vinblastine, followed by maintenance with Palladia.
I hope you never need to know that info, but just in case … now you do.
Customized Home-Cooked Diets: Advantages of Working With a Veterinary Nutritionist
I actually plan to write much more about this session in the coming weeks on my Dog Food Dish Blog, but I’ll just say here that homemade foods, with the help of a veterinary nutritionist, is often a good solution for dogs needing help because of:
- Adverse food responses / food allergies + kidney disease
- Adverse food responses / food allergies + fat intake issues (like pancreatitis)
- Needing a feeding tube
Our local and blogging friend K from Romping and Rolling in the Rockies is a good example of reason #2. I did a whole Q&A about homemade, medically necessary food a while back on the other blog.
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I absolutely did NOT mean to write about such heavy topics at a time when everyone’s mood is full of summer and holiday weekend plans, so we’ll continue this discussion later with some of the other sessions I attended.
Lilly and I wish you a happy, happy Independence Day weekend. Be safe!
Hi Roxanne,
This weekend, I recorded 6 audios for Nikki’s osteosarcoma site. I thought you might be interested. I am getting great feedback from not only dog owners, but from people who have lost human loved ones from osteosarcoma.
Here are the links:
http://nikkisstory.com/about-nikki-nikkis-mom-site-navigation A very brief recap of Nikki’s former lives with me
http://nikkisstory.com/nikkis-story-osteosarcoma-diagnosis When Nikki was diagnosed with osteosarcoma
http://nikkisstory.com/mission-statement Our mission statement, why the site was built
http://nikkisstory.com/canine-osteosarcoma-loss-grieving-for-my-dog-nikki.html Grieving for Nikki as part of “our pack”
http://nikkisstory.com/nikki’s-story-canine-osteosarcoma-treatment-afterthoughts.html His treatment after thoughts
http://nikkisstory.com/why-osteosarcoma.html Why osteosarcoma?
Roxanne, I’m praying your Mom is on the mend.
Julia
Thanks for the update, Julia … and for your good wishes.
Hi Bernice, Roxanne,
My post on Resveratrol and Canine Osteosarcoma is up. If you’d like to take a look, it’s at http://nikkisstory.com/canine-osteosarcoma-k9-osa-resveratrol-treatment.html
Best,
Julia
Thanks so much for sharing the link. We posted it both on Twitter and Facebook.
Hi Roxanne,
Letting you know you have a link from http://NikkisStory.com
Love your site. Best to Lilly.
Julia
Bernice,
I have Resvantage Canine on my “to research” list.
Thanks for the tip.
Julia
Hi Roxanne, any day is a good day for interesting information! In fact, I’d love to learn more.
Hi Roxanne,
I thought you might be interested in my recent post on Palladia at http://nikkisstory.com/palladia-canine-osteosarcoma-studies.html referencing mast cell tumors and new studies underway for Palladia for treatment of canine osteosarcoma.
Additionally, the post includes information on the use of Vascustatin for angiogeneis.
Love your site. It’s fun and very informative.
Best,
Julia
Thanks, Julia. I’ll check it out.
Hi Julia, so glad I came across your comment. Very interested in the comment and very happy I found your blog this way.
I wanted to make you aware of a supplement that I’ve started to treat my dog with. It’s a resveratrol supplement called Resvantage Canine. In numerous studies (please see the links listed below for studies) “resveratrol has been shown to reduce timor incidence in animals […] and may be an effective chemopreventive agent in three stages of cancer” (National Cancer Institute). Additionally, I wanted to bring to your attention that in the testimonial section for Resvantage Canine there is a case of a dog that had bone cancer and after daily use of the product went into remission.
http://www.cancer.gov/cancertopics/factsheet/prevention/redwine
http://www.ncbi.nlm.nih.gov/pubmed/19702538
http://www.resvantagecanine.com
Thank you Jada,
I am hoping it will help other dogs with cancer and specifically canine osteosarcoma. It is such an aggressive cancer that one almost needs a running start when it is first diagnosed.
I wish I had known all the treatments available when Nikki was first diagnosed.
Interestingly, much of the alternative help I have uncovered has been extracted from holistic help for humans. Some protocols have a 90% cure rate for people that most of us just don’t know about.
I feel like a dog digging for a huge, juicy bone as I uncover all this information. I really hopes it helps someone looking for answers.
Best,
Julia
Hi again Bernice and Roxanne,
I am still reviewing the info on Resveratrol for a post on NikkisStory.com There is definite evidence that it can help osteosarcoma.
Also wanted to give you a heads up on a pdf on Resveratrol you can download, thanks to Natural News.
http://www.naturalnews.com/files/Resveratrol_and_its_Effects_on_Human_Health_and_Longevity.pdf
Best,
Julia
P.S. Nikki now has a Squidoo Lens at http://www.squidoo.com/canine-osteosarcoma-diagnosis-and-treatment